Tetramethoxyamphetamine

Tetramethoxyamphetamine (TMA-4) is a psychedelic drug and substituted amphetamine of the phenethylamine class. It is known for its hallucinogenic effects and has been used recreationally and in the context of psychedelic therapy.

History

Tetramethoxyamphetamine was first synthesized in the late 20th century, following the discovery and synthesis of other substituted amphetamines such as mescaline and 3,4,5-trimethoxyamphetamine (TMA). Its effects were first documented in the scientific literature in the 1970s.

Pharmacology

Tetramethoxyamphetamine is a serotonin receptor agonist, meaning it binds to and activates these receptors in the brain. It is thought to exert its psychedelic effects primarily through its action on the 5-HT2A receptor, although it also has affinity for other serotonin receptor subtypes.

Effects

The effects of tetramethoxyamphetamine are similar to those of other psychedelic amphetamines, and include hallucinations, altered perception of time and space, enhanced introspection, and emotional intensification. These effects can last for several hours, depending on the dose and individual user's metabolism.

Legal status

Tetramethoxyamphetamine is a controlled substance in many countries, including the United States, where it is classified as a Schedule I drug under the Controlled Substances Act. This means it is illegal to manufacture, distribute, or possess without a license or prescription.

See also

• Phenethylamine
• Psychedelic drug
• Substituted amphetamine