2C-TFM

2C-TFM is a psychedelic drug and phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin and documented in his book PiHKAL (Phenethylamines I Have Known And Loved).

Chemistry

2C-TFM, or 2,5-dimethoxy-4-(trifluoromethyl)phenethylamine, is a synthetic phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. It has two methoxy groups (OCH3) attached to carbons R2 and R5 as well as a trifluoromethyl group attached to carbon R4 of the phenyl ring. 2C-TFM is analogous to the phenethylamine 2C-T-7, but instead of a 4-methyl group, it has a 4-trifluoromethyl group.

Pharmacology

The exact mechanism of action for 2C-TFM is not well understood, but it is believed to work, like other psychedelics, primarily by binding to serotonin receptors in the brain. Specifically, it likely acts as an agonist at the 5-HT2A receptor, which is responsible for its psychedelic effects.

Effects

The effects of 2C-TFM can vary greatly depending on the dose, individual physiology, and set and setting. Common effects reported by users include open and closed-eye visuals, euphoria, time distortion, enhanced introspection, and increased empathy. However, it can also cause negative effects such as anxiety, paranoia, and uncomfortable body sensations.

Legality

As of 2021, 2C-TFM is not specifically listed in the United Nations' Convention on Psychotropic Substances, but it may be considered illegal in many countries under analogue laws. In the United States, it is considered a Schedule I drug under the Controlled Substances Act.

See also

• 2C (psychedelics)
• Designer drug
• Psychedelic drug
• Alexander Shulgin

2C-TFM Resources
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