N-Methylphenethylamine

N-Methylphenethylamine (NMPEA) is a naturally occurring trace amine neuromodulator in humans that is derived from the amino acid phenylalanine. It has been detected in human urine (<1 μg over 24 hours) and is produced by phenylethanolamine N-methyltransferase with phenethylamine as the substrate. PEA and NMPEA are both alkaloids that are found in a number of different plant species as well. Some Acacia species, such as A. rigidula, contain remarkably high levels of NMPEA.

Pharmacology

NMPEA is a pressor, with 1/350 the potency of epinephrine. It is not currently a controlled substance in the United States. It is used in the manufacture of pharmaceuticals and as a reference standard in forensic and toxicology labs.

See also

• Phenethylamine
• Phenylethanolamine N-methyltransferase
• Trace amine

External links

• ChemBlink.com Compound Information for NMPEA

N-Methylphenethylamine Resources
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