Trimethoxyamphetamine

Trimethoxyamphetamine (TMA) is a class of psychedelic drugs known for their hallucinogenic and empathogenic effects. It is a derivative of amphetamine, specifically, it is the 3,4,5-trimethoxy derivative of amphetamine.

History

TMA was first synthesized by the chemist Alexander Shulgin and documented in his book PiHKAL. The drug was initially used in experimental settings due to its psychoactive effects, but its use has since spread to recreational contexts.

Pharmacology

TMA acts as a serotonin receptor agonist. It also has some activity at the norepinephrine and dopamine receptors. The drug's effects are thought to be primarily due to its action on the serotonin 2A receptor (5-HT2A).

Effects

The effects of TMA are similar to those of other psychedelic drugs. Users often report intense visual hallucinations, altered thought processes, and heightened emotional sensitivity. The drug's effects can last for several hours, with the peak typically occurring 2-4 hours after ingestion.

Risks

Like other psychedelic drugs, TMA carries risks. These include psychological distress, such as anxiety and paranoia, as well as physical risks like increased heart rate and blood pressure. There is also the potential for dangerous interactions with other drugs.

Legal Status

The legal status of TMA varies by country. In many places, it is classified as a controlled substance, making its manufacture, sale, or possession illegal.

See Also

• Phenethylamine
• Psychedelic drug
• Alexander Shulgin
• PiHKAL