3,4,5-Trimethoxyamphetamine
A psychoactive drug of the phenethylamine and amphetamine chemical classes
3,4,5-Trimethoxyamphetamine | |
---|---|
![]() | |
INN | |
Drug class | |
Routes of administration | Oral |
Pregnancy category | |
Bioavailability | |
Metabolism | |
Elimination half-life | |
Excretion | |
Legal status | Uncontrolled |
CAS Number | 2234-16-4 |
PubChem | 4446 |
DrugBank | |
ChemSpider | 4291 |
KEGG |
3,4,5-Trimethoxyamphetamine (TMA) is a psychoactive drug of the phenethylamine and amphetamine chemical classes. It is known for its hallucinogenic effects and is structurally related to other psychedelic compounds such as mescaline.
Chemical structure and properties[edit | edit source]
3,4,5-Trimethoxyamphetamine is a substituted amphetamine, characterized by the presence of three methoxy groups attached to the benzene ring of the amphetamine backbone. The chemical formula is C12H19NO3, and it has a molecular weight of 225.29 g/mol.
Pharmacology[edit | edit source]
TMA acts primarily as a serotonin receptor agonist, particularly at the 5-HT2A receptor, which is believed to be responsible for its psychedelic effects. The compound also has affinity for other serotonin receptors, contributing to its overall psychoactive profile.
Effects[edit | edit source]
The effects of 3,4,5-Trimethoxyamphetamine are similar to those of other psychedelic drugs, including altered perception, mood, and cognition. Users may experience visual hallucinations, changes in thought patterns, and an altered sense of time. The intensity and duration of effects can vary based on dosage and individual sensitivity.
History and usage[edit | edit source]
TMA was first synthesized by the chemist Alexander Shulgin, who documented its effects in his book PiHKAL: A Chemical Love Story. It has been used primarily in research settings to study the effects of psychedelics on the human mind.
Legal status[edit | edit source]
3,4,5-Trimethoxyamphetamine is not a controlled substance in many countries, but its legal status can vary. It is important to check local regulations before acquiring or using this compound.
Related compounds[edit | edit source]
See also[edit | edit source]
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD