Norepinephrine releasing agents

Norepinephrine releasing agents (NRAs) are a type of drug that increase the level of norepinephrine (also known as noradrenaline) in the brain. They are used in the treatment of various medical conditions, including attention deficit hyperactivity disorder (ADHD), depression, and certain types of chronic pain.

Mechanism of action

NRAs work by stimulating the release of norepinephrine from nerve endings in the brain. This increases the concentration of norepinephrine in the synaptic cleft, the space between neurons where signal transmission occurs. Norepinephrine is a neurotransmitter that plays a key role in regulating mood, attention, and pain perception.

Uses

NRAs are used in the treatment of several medical conditions. They are commonly used as stimulants in the treatment of ADHD, where they help to increase attention and reduce impulsivity and hyperactivity. They are also used in the treatment of depression, particularly in cases where other treatments have been ineffective. In addition, some NRAs are used in the management of chronic pain, particularly neuropathic pain.

Examples

Examples of NRAs include amphetamine, methylphenidate, and atomoxetine. These drugs are all used in the treatment of ADHD. Other examples include reboxetine and viloxazine, which are used in the treatment of depression.

Side effects

Like all drugs, NRAs can have side effects. These can include insomnia, anxiety, increased heart rate, and increased blood pressure. In rare cases, they can cause more serious side effects such as psychosis or cardiac arrhythmia.

See also

• Norepinephrine reuptake inhibitor
• Norepinephrine-dopamine reuptake inhibitor
• Monoamine releasing agent