Norepinephrine releasing agent

Norepinephrine releasing agent (NRA) is a type of drug that induces the release of norepinephrine (also known as noradrenaline) and epinephrine (adrenaline) from the sympathetic nervous system and adrenal medulla. NRAs are used in the treatment of various medical conditions, including attention deficit hyperactivity disorder (ADHD), narcolepsy, and depression.

Mechanism of action

NRAs work by increasing the amount of norepinephrine and epinephrine in the synaptic cleft between neurons. This is achieved by promoting the release of these neurotransmitters from their storage vesicles in the presynaptic neuron, thereby enhancing neurotransmission.

Pharmacology

The pharmacological effects of NRAs are primarily due to their ability to stimulate the adrenergic receptors. These receptors are found on the surface of many different types of cells throughout the body, and are involved in a wide range of physiological responses, including the regulation of heart rate, blood pressure, and glucose metabolism.

Clinical uses

NRAs are used in the treatment of a variety of medical conditions. For example, they are used as stimulants in the treatment of ADHD and narcolepsy, and as antidepressants in the treatment of depression. They are also used in the management of orthostatic hypotension, a condition characterized by a drop in blood pressure upon standing up.

Side effects

The side effects of NRAs can include insomnia, anxiety, palpitations, and hypertension. These effects are generally due to the overstimulation of the adrenergic receptors.

See also

• Norepinephrine reuptake inhibitor
• Norepinephrine-dopamine reuptake inhibitor
• Adrenergic receptor