5-HT receptor
5-HT receptors are a group of G protein-coupled receptors and ligand-gated ion channels found in the central and peripheral nervous system. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand.
Types of 5-HT receptors[edit | edit source]
There are seven families of 5-HT receptors, 5-HT1 to 5-HT7, some of which have several subtypes. Each family is further divided into subtypes based on their structural and functional characteristics.
- 5-HT1 receptor - This receptor family includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. They are primarily involved in the inhibition of adenylate cyclase activity.
- 5-HT2 receptor - This family includes 5-HT2A, 5-HT2B, and 5-HT2C. They are primarily involved in the activation of phospholipase C.
- 5-HT3 receptor - This is the only serotonin receptor that is a ligand-gated ion channel, rather than a G protein-coupled receptor.
- 5-HT4 receptor - This receptor is involved in the activation of adenylate cyclase activity.
- 5-HT5 receptor - This family includes 5-HT5A and 5-HT5B. The function of these receptors is still not fully understood.
- 5-HT6 receptor - This receptor is involved in the activation of adenylate cyclase activity.
- 5-HT7 receptor - This receptor is involved in the activation of adenylate cyclase activity.
Role in the body[edit | edit source]
5-HT receptors play a crucial role in a wide range of physiological and pathophysiological conditions. They are involved in the regulation of various behaviors and functions, including mood, anxiety, sleep, and appetite. They are also implicated in a number of disorders, such as depression, schizophrenia, Parkinson's disease, and irritable bowel syndrome.
See also[edit | edit source]
References[edit | edit source]
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