25D-NBOMe

25D-NBOMe2DACS

25D-NBOMe is a psychedelic drug that belongs to the NBOMe series of substituted phenethylamines. It is closely related to other compounds in the NBOMe series, such as 25I-NBOMe, 25C-NBOMe, and 25B-NBOMe, which are known for their potent psychedelic effects and high affinity for the 5-HT2A receptor. The chemical name for 25D-NBOMe is 2-(2,5-dimethoxy-4-n-propyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine.

Chemistry

25D-NBOMe is a derivative of the phenethylamine class of psychedelic drugs, specifically a member of the NBOMe series which is characterized by the addition of a methoxybenzyl (NBOMe) group to the amine nitrogen of the phenethylamine backbone. This modification significantly increases the compound's affinity for the 5-HT2A receptor, making it an extremely potent psychedelic. The "D" in 25D-NBOMe refers to the two methoxy groups located at the 2 and 5 positions of the benzene ring, with an additional propyl group at the 4 position, distinguishing it from its counterparts in the series.

Pharmacology

The pharmacological action of 25D-NBOMe is primarily through agonism of the 5-HT2A receptor, a mechanism of action it shares with other classical psychedelics like LSD and psilocybin. However, the NBOMe series shows a significantly higher potency and selectivity for this receptor, which is thought to underlie their powerful psychedelic effects. The exact pharmacokinetic profile of 25D-NBOMe, including its absorption, distribution, metabolism, and excretion, is not well-documented, reflecting the compound's status as a novel psychoactive substance.

Effects

The effects of 25D-NBOMe are similar to those of other psychedelics in the NBOMe series, including intense visual and auditory hallucinations, altered perception of time and space, euphoria, and introspection. However, due to its potency, the risk of negative effects, such as confusion, panic attacks, and dangerous increases in heart rate and blood pressure, is higher. There have also been reports of severe toxic reactions and fatalities associated with the use of NBOMe compounds, highlighting the risks of experimenting with these substances.

Legal Status

The legal status of 25D-NBOMe varies by country, but it has been banned or controlled in several jurisdictions in response to concerns over its safety and potential for abuse. In some countries, it is classified alongside other NBOMe compounds as a controlled substance, making its manufacture, distribution, and possession illegal.

Safety

Due to the limited research on 25D-NBOMe and its analogs, the safety profile of these substances is not well understood. However, the high potency and risk of overdose, coupled with reports of serious adverse effects and fatalities, suggest that these compounds pose significant health risks. Users of 25D-NBOMe and similar substances are advised to exercise extreme caution and be aware of the legal implications of their use.

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