25C-NBOMe

2C-C-NBOMe

25C-NBOMe blotter

Psychedelic drug

25C-NBOMe
Chemical nomenclature
IUPAC name	2-(4-Chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethan-1-amine
Identifiers
CAS Number	1227608-02-7
PubChem	46856354
ChemSpider	24583389
UNII	9FGW3C260N
KEGG	C22720
Chemical data
Chemical formula	C18H22N1O3Cl1
SMILES	COc2ccccc2CNCCc(cc1OC)c(OC)cc1Cl
InChI	1S/C18H22ClNO3/c1-21-16-7-5-4-6-14(16)12-20-9-8-13-10-18(23-3)15(19)11-17(13)22-2/h4-7,10-11,20H,8-9,12H2,1-3H3
InChIKey	FJFPOGCVVLUYAQ-UHFFFAOYSA-N

25C-NBOMe is a synthetic psychedelic compound that belongs to the NBOMe series of psychedelic drugs. It is chemically related to 2C-C (4-chloro-2,5-dimethoxyphenethylamine) from the 2C family of psychedelics which are part of the larger group of phenethylamine derivatives. 25C-NBOMe was first synthesized and studied by Ralf Heim at the Free University of Berlin in 2003. It acts primarily as a potent agonist for the 5-HT2A receptor, leading to its psychedelic effects.

Chemistry

25C-NBOMe is a derivative of the phenethylamine psychedelic 2C-C. It is specifically modified by adding a methoxybenzyl (NBOMe) group to the nitrogen (N) of the ethyl chain of 2C-C. This modification significantly increases its potency compared to its parent compound. The full chemical name of 25C-NBOMe is 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine.

Pharmacology

The primary mechanism of action of 25C-NBOMe involves its function as an agonist at the 5-HT2A receptor. The activation of this receptor is responsible for the compound's psychedelic effects. 25C-NBOMe has been found to be extremely potent, with active doses in the microgram range, making it significantly more potent than other classical psychedelics such as LSD or psilocybin.

Effects

The effects of 25C-NBOMe can vary greatly and can include both physical and psychological effects. Physical effects may include nausea, vasoconstriction, increased heart rate, and increased blood pressure. Psychological effects can include visual and auditory hallucinations, altered perception of time and space, euphoria, and introspection. The effects can last anywhere from 6 to 10 hours, depending on the dose and individual metabolism.

Risks and Safety

Due to its high potency and narrow therapeutic index, 25C-NBOMe has been associated with several adverse events, including fatalities. The risks of overdose and poisoning are significantly higher compared to traditional psychedelics. Symptoms of overdose may include severe agitation, cardiac arrest, and seizures. As a result, there is a high potential for harm when using substances like 25C-NBOMe, especially without precise dosing.

Legal Status

The legal status of 25C-NBOMe varies by country, but it has been banned or controlled in several jurisdictions due to concerns over its safety and potential for abuse. In some countries, it is classified as a controlled substance, making its possession, sale, or manufacture illegal.

Analogues and derivatives

Analogues and derivatives of 2C-C:

25C-NB*:

• 25C-NBF
• 25C-NBMD
• 25C-NBOH
• 25C-NBOMe (NBOMe-2CC)
• 25C-NB3OMe
• 25C-NB4OMe

N-(2C)-fentanyl:

• N-(2C-C)-fentanyl