PARGY-LAD

PARGY-LAD (also known as 1P-LSD) is a psychedelic drug that is part of the lysergamide family. It is closely related to LSD and is reported to produce near-identical effects. PARGY-LAD was first synthesized by a team at Purdue University led by David Nichols. It is a derivative and functional analogue of LSD and a homologue of ALD-52. Given that it is a derivative of LSD, it is considered to be a semi-synthetic molecule of the lysergamide class.

Chemistry

PARGY-LAD, or 1-propionyl-6-allyl-6-nor-lysergic acid diethylamide, is a semi-synthetic alkaloid of the lysergamide class. The full name of the chemical is 1-propionyl-6-allyl-6-nor-lysergic acid diethylamide. It is similar in structure to LSD, with an N,N-diethylamide functional group bound to RN of the chemical structure. This core polycyclic structure is an indole derivative, and has tryptamine and phenethylamine groups embedded within it.

Pharmacology

Like LSD, PARGY-LAD likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from PARGY-LAD’s efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Effects

The effects of PARGY-LAD are believed to include cognitive euphoria, distorted perception of colors, time, sounds and shapes, hallucinations, and spontaneous tactile sensations. The effects are reported to be somewhat similar to those of LSD, but with a less intense psychedelic headspace. Subjective effects of PARGY-LAD can include anxiety, visual hallucinations, time distortion, enhanced introspection, ego loss, and auditory hallucinations.

Legal Status

As of 2021, PARGY-LAD is a controlled substance in Latvia, Lithuania, and the United Kingdom. Its legal status in other countries is unclear, but it could potentially be considered an analogue of LSD, and therefore illegal in countries with strong analogue laws, such as the United States.

See Also

• Lysergic acid diethylamide
• Psychedelic drug
• ALD-52