Triprolidine

What is Triprolidine?

• Triprolidine is a first generation antihistamine that is used for symptoms of allergic rhinitis and the common cold and as a short acting sedative.

Triprolidine

Triprolidine Structural Formula V1

What are the uses of this medicine?

Triprolidine temporarily relieves these symptoms due to hay fever (allergic rhinitis) or other upper respiratory allergies:

• runny nose
• sneezing
• itching of the nose or throat
• itchy, watery eyes

How does this medicine work?

• Triprolidine (trye proe' li deen) is a first generation antihistamine that is used to treat the symptoms of the common cold, including sneezing, cough, runny note, watery eyes and itching.
• Triprolidine belongs to the ethanolamine class of antihistamines (with clemastine and dimenhydrinate) and is currently used largely in combination with pseudoephedrine in prescription or over-the-counter products for relief of symptoms of the common cold and allergic rhinitis.

Who Should Not Use this medicine ?

This medicine cannot be used in patients with:

• a breathing problem such as emphysema or chronic bronchitis
• glaucoma
• trouble urinating due to an enlarged prostate gland

What drug interactions can this medicine cause?

• Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Be sure to mention any of the following:

• sedatives or tranquilizers

Is this medicine FDA approved?

• It was patented in 1948 and came into medical use in 1953.

How should this medicine be used?

Recommended dosage:

• The typical adult oral dose is 1 teaspoonful (5 mL) (2.5 mg) 3 to 4 times a day.

Childen 6 to under 12 years of age:

• ½ teaspoonful (2.5 mL) every 4 to 6 hours, not to exceed 2 teaspoonfuls (10 mL) in 24 hours, or as directed by a doctor.

Children under 6 years of age:

• Consult a doctor

Administration:

• Triprolidine comes as syrup containing Triprolidine HCl 2.5 mg.
• Take it every 4 to 6 hours, not to exceed 4 teaspoonfuls (20 mL) in 24 hours, or as directed by a doctor.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As Syrup
• Each teaspoonful (5 mL) contains:
• Triprolidine HCl 2.5 mg

This medicine is available in fallowing brand namesː

• Aprodine and Silafed
• Actidil

What side effects can this medication cause?

The most common side effects of this medicine include:

• sedation, impairment of motor function, confusion, dizziness, blurred vision, dry mouth and throat, palpitations, tachycardia, abdominal distress, constipation and headache.

• Antihistamines can worsen urinary retention and glaucoma.

What special precautions should I follow?

Tell doctor before use if you have:

• a breathing problem such as emphysema or chronic bronchitis
• glaucoma
• trouble urinating due to an enlarged prostate gland
• Tell your doctor before use if you are taking sedatives or tranquilizers.
• When using this product excitability may occur, especially in children.
• Triprolidine may cause drowsiness. use caution when driving a motor vehicle or operating machinery.
• Alcohol, sedatives and tranquilizers may increase the drowsiness effect of Triprolidine. Avoid concomitant use.
• Avoid alcoholic beverages with Triprolidine.
• Stop use and ask a doctor if new symptoms occur.
• If pregnant or breast-feeding, ask a health professional before use.
• Triprolidine has not been linked to instances of clinically apparent acute liver injury.

What to do in case of emergency/overdose?

• In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

• Overdose related information is also available online at poisonhelp.org/help.
• In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.

Can this medicine be used in pregnancy?

• If pregnant, ask a health professional before use.

Can this medicine be used in children?

Children under 6 years of age:

• Consult a doctor.

What are the active and inactive ingredients in this medicine?

Active ingredient:

• TRIPROLIDINE HYDROCHLORIDE

Inactive ingredients:

• Citric Acid, Glycerin, Propylene Glycol, Purified Water, Sodium Citrate, Sodium Saccharin, Sorbitol, Bubble Gum Flavor.

Who manufactures and distributes this medicine?

• Westminster Pharmaceuticals

What should I know about storage and disposal of this medication?

• Store at room temperature 15°-30° C (59°-86° F).
• Tamper evident by foil seal under cap.
• Do not use if foil seal is missing or broken.

First Generation Antihistamines

• Brompheniramine
• Carbinoxamine
• Chlorcyclizine
• Chlorpheniramine
• Clemastine
• Cyclizine
• Cyproheptadine
• Dexbrompheniramine
• Dexchlorpheniramine
• Dimenhydrinate
• Diphenhydramine
• Doxylamine
• Hydroxyzine
• Meclizine
• Phenyltoloxamine
• Promethazine
• Triprolidine

Second Generation Antihistamines

• Acrivastine
• Cetirizine
• Fexofenadine
• Levocetirizine
• Loratadine
• Desloratadine

• Dailymed label info on Triprolidine
• FDA Triprolidine

Triprolidine Resources
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First Generation Antihistamines

• Brompheniramine
• Carbinoxamine
• Chlorcyclizine
• Chlorpheniramine
• Clemastine
• Cyclizine
• Cyproheptadine
• Dexbrompheniramine
• Dexchlorpheniramine
• Dimenhydrinate
• Diphenhydramine
• Doxylamine
• Hydroxyzine
• Meclizine
• Phenyltoloxamine
• Promethazine
• Triprolidine

Second Generation Antihistamines

• Acrivastine
• Cetirizine
• Fexofenadine
• Levocetirizine
• Loratadine
• Desloratadine

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