JWH-424

JWH-424 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent and selective CB₂ agonist. It is part of the JWH series of synthetic cannabinoids, named after the initials of the scientist who first synthesized them, John W. Huffman.

Chemistry

JWH-424 is a member of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073, but it differs in that it is a selective agonist of the CB₂ receptor, rather than the CB₁ receptor. This means that it has a higher affinity for the CB₂ receptor, which is primarily found in the immune system, than for the CB₁ receptor, which is primarily found in the brain.

Pharmacology

As a CB₂ agonist, JWH-424 has potential therapeutic applications in the treatment of pain and inflammation, as well as in immune system modulation. However, like other synthetic cannabinoids, it also has the potential for abuse and adverse health effects. The exact pharmacological profile of JWH-424 is not well-studied, and further research is needed to fully understand its effects and potential risks.

Legal Status

The legal status of JWH-424 varies by country and region. In many places, it is considered a controlled substance due to its potential for abuse and its structural similarity to other controlled synthetic cannabinoids. However, in some jurisdictions, it may be legal for research purposes under certain conditions.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• JWH series