Naphthoylindole

Naphthoylindole is a class of synthetic cannabinoids that are often used in research and have also been sold as designer drugs. The structure of naphthoylindoles consists of a naphthyl group attached to an indole core, hence the name.

Chemistry

Naphthoylindoles are part of a larger family of synthetic cannabinoids, which also includes phenylacetylindoles, cyclohexylphenols, and classical cannabinoids. The common feature of these compounds is the indole core, a bicyclic structure consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. In naphthoylindoles, a naphthyl group (a fused pair of benzene rings) is attached to the indole core.

Pharmacology

Like other synthetic cannabinoids, naphthoylindoles act as agonists at the cannabinoid receptors CB1 and CB2. These receptors are part of the endocannabinoid system, which plays a role in a variety of physiological processes including pain sensation, mood, and memory. The exact mechanism of action of naphthoylindoles is not fully understood, but it is believed to involve modulation of the endocannabinoid system.

Effects

The effects of naphthoylindoles can vary widely depending on the specific compound and the dosage used. However, common effects reported by users include euphoria, relaxation, altered perception, and sometimes psychosis or other serious adverse effects. Due to the potential for serious harm, many countries have banned the sale and possession of synthetic cannabinoids including naphthoylindoles.

Legal Status

The legal status of naphthoylindoles varies by country. In many places, they are classified as controlled substances due to their potential for abuse and harm. However, because these are synthetic compounds, manufacturers often alter the chemical structure to create new versions that are not specifically listed in drug laws, leading to a legal grey area.

See Also

• Synthetic cannabinoids
• Indole
• Naphthyl