JWH-098

Overview

JWH-098 is a synthetic cannabinoid that acts as an agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their psychoactive effects. JWH-098 was developed in the 1990s by John W. Huffman and his team at Clemson University as part of their research into the structure-activity relationships of cannabinoids.

Chemical Structure

Chemical structure of JWH-098

JWH-098 is chemically classified as a naphthoylindole, which is characterized by a naphthalene group attached to an indole core. The specific structure of JWH-098 includes a 1-pentyl-3-(1-naphthoyl)indole framework. This structure is similar to other synthetic cannabinoids, such as JWH-018 and JWH-073, but with slight variations that affect its binding affinity and potency.

Pharmacology

JWH-098 acts as a full agonist at the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes, including mood, appetite, and pain sensation. The activation of these receptors by JWH-098 can lead to effects similar to those of THC, the primary psychoactive component of cannabis.

Effects and Usage

The effects of JWH-098 are similar to those of other synthetic cannabinoids, including euphoria, altered perception, and relaxation. However, due to its synthetic nature, the potency and duration of effects can vary significantly. JWH-098 and similar compounds have been used recreationally, often marketed as "spice" or "herbal incense." These products are typically sprayed onto plant material and smoked.

Legal Status

The legal status of JWH-098 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. The DEA and other regulatory bodies have placed JWH-098 and similar compounds under Schedule I, indicating a high potential for abuse and no accepted medical use.

Safety and Toxicity

The safety profile of JWH-098 is not well-established, as it has not been extensively studied in humans. However, synthetic cannabinoids, in general, have been associated with adverse effects, including tachycardia, hypertension, hallucinations, and psychosis. The variability in potency and purity of products containing JWH-098 can increase the risk of overdose and other harmful effects.

Related pages

• Synthetic cannabinoids
• Cannabinoid receptor
• JWH-018
• JWH-073