CB2 receptor
CB2 receptor is a G protein-coupled receptor from the cannabinoid receptor family of receptors. It is primarily found in the immune system, with its highest concentration in the spleen. CB2 receptors are also found in the gastrointestinal system, where they modulate intestinal inflammatory response.
Function[edit | edit source]
The CB2 receptor is activated by cannabinoids, a class of compounds which includes the active components of cannabis. When activated, the receptor can have effects such as reducing inflammation and pain. It is also involved in a variety of other processes, including immune suppression and apoptosis (programmed cell death).
Therapeutic potential[edit | edit source]
Because of its role in controlling inflammation and immune response, the CB2 receptor is a potential target for the treatment of a variety of conditions, including chronic pain, inflammatory bowel disease, and neurodegenerative diseases. Several drugs that target the CB2 receptor are currently in clinical trials.
Ligands[edit | edit source]
A number of ligands bind to and activate the CB2 receptor. These include both endogenous cannabinoids produced in the body, such as anandamide and 2-AG, and exogenous cannabinoids, such as the THC found in cannabis.
See also[edit | edit source]
This GPCR-related article is a stub. You can help WikiMD by expanding it.
 | This protein-related article is a stub. You can help WikiMD by expanding it. |
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
