CB2 receptor

CB2 receptor is a G protein-coupled receptor from the cannabinoid receptor family of receptors. It is primarily found in the immune system, with its highest concentration in the spleen. CB2 receptors are also found in the gastrointestinal system, where they modulate intestinal inflammatory response.

Function

The CB2 receptor is activated by cannabinoids, a class of compounds which includes the active components of cannabis. When activated, the receptor can have effects such as reducing inflammation and pain. It is also involved in a variety of other processes, including immune suppression and apoptosis (programmed cell death).

Therapeutic potential

Because of its role in controlling inflammation and immune response, the CB2 receptor is a potential target for the treatment of a variety of conditions, including chronic pain, inflammatory bowel disease, and neurodegenerative diseases. Several drugs that target the CB2 receptor are currently in clinical trials.

Ligands

A number of ligands bind to and activate the CB2 receptor. These include both endogenous cannabinoids produced in the body, such as anandamide and 2-AG, and exogenous cannabinoids, such as the THC found in cannabis.

See also

• Cannabinoid receptor
• Endocannabinoid system
• Medical cannabis

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