VU-0152100
VU-0152100 is a chemical compound that acts as a selective positive allosteric modulator of the metabotropic glutamate receptor subtype mGluR4. It is primarily used in scientific research to study the role of mGluR4 in the central nervous system and its potential therapeutic applications.
Mechanism of Action[edit | edit source]
VU-0152100 functions by binding to an allosteric site on the mGluR4 receptor, which is distinct from the orthosteric site where the endogenous ligand, glutamate, binds. This binding enhances the receptor's response to glutamate, thereby modulating neurotransmission. The mGluR4 receptor is a G-protein coupled receptor (GPCR) that is involved in the regulation of neurotransmitter release in the brain.
Pharmacological Effects[edit | edit source]
The activation of mGluR4 by VU-0152100 has been shown to have several effects in preclinical models:
- Neuroprotection: VU-0152100 has demonstrated neuroprotective effects in models of Parkinson's disease, suggesting its potential as a therapeutic agent for neurodegenerative disorders.
- Analgesia: Modulation of mGluR4 has been associated with analgesic effects, indicating a possible role in pain management.
- Anxiolytic Effects: Studies have shown that VU-0152100 may reduce anxiety-like behaviors, which could be beneficial in treating anxiety disorders.
Research Applications[edit | edit source]
VU-0152100 is used extensively in research to explore the therapeutic potential of mGluR4 modulation. It serves as a tool compound to:
- Investigate the role of mGluR4 in various neurological and psychiatric disorders.
- Develop new therapeutic strategies targeting mGluR4 for conditions such as schizophrenia, anxiety disorders, and chronic pain.
Safety and Toxicology[edit | edit source]
As a research compound, VU-0152100 is not approved for clinical use in humans. Its safety profile is primarily characterized in animal studies, where it has shown a favorable safety margin. However, further studies are required to fully understand its toxicological properties.
Also see[edit | edit source]
- Metabotropic glutamate receptor
- Allosteric modulator
- Neurotransmission
- Parkinson's disease
- G-protein coupled receptor
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
