5F-NNE1

5F-NNE1 (also known as 5F-NNEI and MN-24) is an indole-based synthetic cannabinoid that has been sold online as a designer drug and is presumed to be a potent agonist of the CB1 receptor. It is the 5-fluoropentyl analog of NNE1. Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of 5F-NNE1 may release 1-naphthylamine, a known carcinogen.

Pharmacology

5F-NNE1 is believed to be a strong agonist of the CB1 receptor, although it is unclear whether it is selective for this target. 5F-NNE1 is presumed to be metabolized in the body to remove the amide group, releasing 1-naphthylamine.

Legality

As of October 2015, 5F-NNE1 is a controlled substance in China. It is also banned in many other countries due to its psychoactive properties and potential health risks.

See also

• Cannabinoid
• CB1 receptor
• Designer drug
• Synthetic cannabinoids

References

5F-NNE1 Resources
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