Lisuride

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Lisuride is a medication and psychedelic drug of the ergoline family. It is used in the treatment of Parkinson's disease and cluster headache. It is a derivative of lysergic acid, which is also the precursor of LSD. Lisuride is described as a dopamine agonist because it stimulates dopamine receptors in the brain.

Pharmacology[edit | edit source]

Lisuride is known to be an antagonist or agonist of various receptors, such as the serotonin receptors (5-HT2B and 5-HT2C) and the dopamine receptors (D2 and D3). It is also an antagonist at the histamine receptors and adrenergic receptors.

Medical uses[edit | edit source]

Lisuride is used to lower prolactin and, in low doses, to prevent migraine attacks. The use of lisuride as initial therapy for Parkinson's disease is no longer recommended due to marked side effects related to the non-ergoline derivatives. It is still used in patients with Parkinson's disease who have become refractory to levodopa therapy.

Side effects[edit | edit source]

Common side effects of lisuride include hallucinations, psychosis, nausea, orthostatic hypotension, and abnormal involuntary movements. Rare side effects include retroperitoneal fibrosis and pleural fibrosis.

History[edit | edit source]

Lisuride was first synthesized in 1976 by the pharmaceutical company Sandoz. It was introduced to the market in the 1980s for the treatment of Parkinson's disease.

See also[edit | edit source]

Template:Psychedelic-stub

Resources[edit source]

Latest articles - Lisuride

PubMed
Clinical trials
UpToDate

AI tools[edit source]

Generative AI tools and links to learn more on Lisuride: ChatGPT - Bing Chat - Google Gemini. (caution advised).


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