Methapyrilene

Methapyrilene is an antihistamine and anticholinergic of the pyridine chemical class which was developed in the early 1950s. It was used in over-the-counter drugs as a night-time aid for the relief of allergy symptoms, and was also used in the treatment of Parkinson's disease and other motion sickness disorders. However, it was withdrawn from the market due to causing cancer in rats.

History

Methapyrilene was first developed in the early 1950s as an antihistamine and anticholinergic. It was widely used in over-the-counter drugs as a night-time aid for the relief of allergy symptoms. It was also used in the treatment of Parkinson's disease and other motion sickness disorders.

In the 1970s, studies found that methapyrilene caused cancer in rats. As a result, it was withdrawn from the market.

Uses

Methapyrilene was used as a night-time aid for the relief of allergy symptoms. It was also used in the treatment of Parkinson's disease and other motion sickness disorders.

Side Effects

The side effects of methapyrilene include drowsiness, dizziness, blurred vision, dry mouth, constipation, and difficulty urinating.

Withdrawal

Methapyrilene was withdrawn from the market after studies found that it caused cancer in rats.

See Also

• Antihistamine
• Anticholinergic
• Pyridine

Methapyrilene Resources
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