Cyamemazine
Cyamemazine[edit | edit source]
Cyamemazine is a typical antipsychotic medication primarily used in the treatment of schizophrenia and other psychotic disorders. It belongs to the class of phenothiazines, which are known for their antipsychotic and sedative properties. Cyamemazine is unique among phenothiazines due to its additional anxiolytic effects, making it useful in treating anxiety-related symptoms in psychotic patients.
Pharmacology[edit | edit source]
Cyamemazine acts as an antagonist at various neurotransmitter receptors, including dopamine D2, serotonin 5-HT2A, and histamine H1 receptors. This broad receptor activity contributes to its antipsychotic, anxiolytic, and sedative effects. The blockade of dopamine receptors in the central nervous system is primarily responsible for its antipsychotic action, while the antagonism of serotonin receptors may enhance its anxiolytic properties.
Clinical Uses[edit | edit source]
Cyamemazine is indicated for the management of schizophrenia and other psychotic disorders. Its anxiolytic properties make it particularly beneficial for patients who experience significant anxiety alongside psychotic symptoms. Additionally, cyamemazine is sometimes used off-label for the treatment of severe anxiety disorders.
Side Effects[edit | edit source]
Common side effects of cyamemazine include sedation, dry mouth, constipation, and orthostatic hypotension. Like other antipsychotics, it may cause extrapyramidal symptoms such as tremors, rigidity, and akathisia. Long-term use can lead to tardive dyskinesia, a potentially irreversible condition characterized by involuntary movements.
Synthesis[edit | edit source]
The synthesis of cyamemazine involves the chemical modification of the phenothiazine core structure. The process typically includes the introduction of a cyano group and a dimethylaminopropyl side chain, which are crucial for its pharmacological activity. The synthesis pathway is designed to optimize the yield and purity of the final product, ensuring its efficacy and safety as a medication.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
