JWH-051

JWH-051 is a synthetic cannabinoid from the naphthoylindole family, which acts as a partial agonist at both the CB1 and CB2 cannabinoid receptors. It is one of the first non-classical cannabinoids discovered, named after the researcher John W. Huffman who first synthesized these compounds.

Chemistry

JWH-051 is a member of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids like JWH-018 and JWH-073. The compound is made by substituting an alkyl group at the nitrogen atom of the indole core, and a naphthoyl group at the carbonyl group of the indole.

Pharmacology

JWH-051 acts as a partial agonist at both the CB1 and CB2 cannabinoid receptors. The CB1 receptor is primarily located in the brain, and mediates the psychoactive effects of cannabinoids. The CB2 receptor is found primarily in the immune system, and is involved in regulation of immune function and inflammation.

Effects

The effects of JWH-051 are similar to those of other synthetic cannabinoids and include psychoactive effects and potential for cannabis-like side effects such as dry mouth, increased heart rate, and potential for psychological dependence.

Legal Status

The legal status of JWH-051 varies by country and is often subject to change. In many jurisdictions, it is classified as a controlled substance due to its structural similarity to other banned synthetic cannabinoids.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman