Nitroxazepine

Nitroxazepine is a tricyclic antidepressant (TCA) that was developed in the 1960s but was never marketed. It is a derivative of imipramine where one of the benzene rings has been replaced with a pyridine ring.

Pharmacology

Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor (SNRI) and also has other activities including antihistamine, anticholinergic, and antiadrenergic effects.

Chemistry

The chemical structure of nitroxazepine is similar to other tricyclic antidepressants but with a pyridine ring instead of a benzene ring. This gives it unique properties compared to other TCAs.

History

Nitroxazepine was developed in the 1960s as part of a series of compounds with potential antidepressant activity. However, it was never marketed, possibly due to its side effect profile or lack of efficacy compared to other drugs available at the time.

See also

• Tricyclic antidepressant
• Serotonin-norepinephrine reuptake inhibitor
• Antidepressant

Nitroxazepine Resources
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