Indacaterol/glycopyrronium bromide

Indacaterol/glycopyrronium bromide is a combination drug used for the treatment of chronic obstructive pulmonary disease (COPD). It contains two active ingredients: indacaterol, a long-acting beta-adrenoceptor agonist (LABA), and glycopyrronium bromide, a long-acting muscarinic antagonist (LAMA).

Etymology

The name "indacaterol" is derived from the chemical structure of the drug, which includes an indanone and a catechol. The name "glycopyrronium bromide" is derived from the chemical structure of the drug, which includes a quaternary ammonium cation and a bromide anion.

Pharmacology

Indacaterol works by stimulating beta-2 adrenergic receptors in the lungs, which causes relaxation of the bronchial smooth muscle. This results in bronchodilation and improved airflow. Glycopyrronium bromide works by blocking muscarinic receptors in the lungs, which inhibits the contraction of the bronchial smooth muscle. This also results in bronchodilation and improved airflow.

Clinical use

Indacaterol/glycopyrronium bromide is used for the maintenance treatment of COPD. It is not used for the relief of acute bronchospasm or for the treatment of asthma.

Side effects

Common side effects of indacaterol/glycopyrronium bromide include cough, throat irritation, and upper respiratory tract infection. Less common side effects include palpitations, muscle spasms, and urinary retention.

Related terms

• Bronchodilator
• Muscarinic antagonist
• Beta-2 adrenergic agonist
• Chronic obstructive pulmonary disease

• Indacaterol and glycopyrronium bromide
  Indacaterol and glycopyrronium bromide