JWH-166
Overview[edit | edit source]
JWH-166 is a synthetic cannabinoid that belongs to the naphthoylindole family. It was developed by Dr. John W. Huffman and his team at Clemson University as part of their research into the endocannabinoid system. JWH-166 is known for its high affinity for the CB2 receptor, which is primarily found in the peripheral tissues and immune cells.
Chemical Structure[edit | edit source]
JWH-166 is chemically classified as a naphthoylindole. Its systematic IUPAC name is (4-methoxynaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone. The compound has a molecular formula of C25H25NO2 and a molecular weight of 371.47 g/mol.
Pharmacology[edit | edit source]
JWH-166 acts as a potent agonist at the CB2 receptor, with a much lower affinity for the CB1 receptor, which is predominantly located in the central nervous system. This selectivity makes JWH-166 of interest for potential therapeutic applications that aim to avoid the psychoactive effects associated with CB1 receptor activation.
Mechanism of Action[edit | edit source]
JWH-166 binds to the CB2 receptor, which is a G-protein coupled receptor (GPCR). Upon binding, it activates intracellular signaling pathways that can modulate immune responses and inflammation. This mechanism is similar to that of endogenous cannabinoids, such as 2-arachidonoylglycerol (2-AG) and anandamide, which also interact with cannabinoid receptors.
Potential Applications[edit | edit source]
Due to its selectivity for the CB2 receptor, JWH-166 has been studied for its potential use in treating conditions such as chronic pain, inflammation, and autoimmune diseases. The activation of CB2 receptors has been shown to have anti-inflammatory effects, which could be beneficial in these conditions.
Legal Status[edit | edit source]
The legal status of JWH-166 varies by country. In many jurisdictions, synthetic cannabinoids are controlled substances due to their potential for abuse and lack of medical approval. Researchers must comply with local regulations when studying these compounds.
Safety and Toxicology[edit | edit source]
As with many synthetic cannabinoids, the safety profile of JWH-166 is not well-established. Potential side effects may include immune modulation, which could lead to unintended consequences in the body's ability to fight infections or cancer. Further research is needed to fully understand the toxicological implications of JWH-166.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD