Org 27569

Org 27569 is a drug that acts as a potent and selective allosteric modulator of the cannabinoid CB1 receptor, with a novel mechanism of action. It was developed by Organon International, a pharmaceutical company based in the Netherlands.

Mechanism of Action

Unlike most CB1 antagonists, Org 27569 does not block the receptor. Instead, it changes the shape of the receptor, making it less responsive to certain types of stimulation. This is known as allosteric modulation. Org 27569 is the first drug of this kind to be discovered, and its unique mechanism of action has made it a valuable tool for researching the CB1 receptor.

Pharmacology

Org 27569 has been found to inhibit the effects of cannabinoids such as THC, the active ingredient in cannabis. However, it does not produce the same effects as other CB1 antagonists, such as Rimonabant, which can cause depression and anxiety. This suggests that Org 27569 may have potential as a treatment for cannabis dependence.

Clinical Trials

As of 2021, Org 27569 has not been tested in clinical trials. However, preclinical studies have shown promising results, and further research is ongoing.

See Also

• Allosteric modulator
• Cannabinoid receptor
• Cannabis dependence