Lysophosphatidylinositol
Lysophosphatidylinositol (LPI) is a bioactive lipid that acts as a secondary messenger in the cell signaling process. It is a member of the lysophospholipid (LPL) family, which are lipids that have been modified by the addition of a phosphate group. LPI plays a crucial role in various biological processes, including cell proliferation, differentiation, and survival.
Structure[edit | edit source]
Lysophosphatidylinositol is composed of a glycerol backbone, a phosphate group, and a fatty acid chain. The glycerol backbone is linked to the phosphate group at the sn-3 position, and the fatty acid chain is attached to the glycerol backbone at the sn-1 position. This structure is what distinguishes LPI from other lysophospholipids, which have their fatty acid chains attached at the sn-2 position.
Function[edit | edit source]
Lysophosphatidylinositol functions as a signaling molecule in the body. It binds to the G protein-coupled receptor GPR55, which is involved in a variety of physiological processes, including pain perception, bone growth, and blood pressure regulation. LPI can also act as a ligand for other receptors, such as the cannabinoid receptor CB1 and CB2.
In addition to its role in cell signaling, LPI has been found to have other biological functions. For example, it can act as a mitogen, stimulating cell division and growth. It can also promote cell survival by inhibiting apoptosis, or programmed cell death.
Clinical significance[edit | edit source]
Abnormal levels of Lysophosphatidylinositol have been associated with various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. For example, elevated levels of LPI have been found in the blood of patients with ovarian cancer, suggesting that it may play a role in the development or progression of this disease. Similarly, decreased levels of LPI have been observed in the brains of patients with Alzheimer's disease, suggesting a potential role in neurodegeneration.
See also[edit | edit source]
.svg){kind=small} | This biochemistry article is a stub. You can help WikiMD by expanding it. |
```
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
