JWH-133
Overview[edit | edit source]
JWH-133 is a synthetic cannabinoid that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a high affinity and selectivity over the CB1 receptor. It is part of the naphthoylindole family of synthetic cannabinoids, which were originally developed for research purposes to study the endocannabinoid system.
Chemical Properties[edit | edit source]
JWH-133 is chemically classified as a naphthoylindole, which is a type of synthetic cannabinoid. Its chemical structure is characterized by a naphthoyl group attached to an indole core. The molecular formula of JWH-133 is C23H21NO, and it has a molecular weight of 327.42 g/mol.
Pharmacology[edit | edit source]
JWH-133 is known for its high selectivity towards the CB2 receptor, which is primarily found in the immune system and peripheral tissues. This selectivity makes it a valuable tool in research for understanding the role of CB2 receptors in various physiological and pathological processes. Unlike CB1 receptors, which are predominantly located in the central nervous system, CB2 receptors are not associated with the psychoactive effects typically linked to cannabinoids.
Mechanism of Action[edit | edit source]
JWH-133 functions as an agonist at the CB2 receptor, meaning it binds to and activates this receptor. Activation of CB2 receptors by JWH-133 can lead to anti-inflammatory and immunomodulatory effects, which are of interest in the study of diseases such as multiple sclerosis, arthritis, and other inflammatory conditions.
Research Applications[edit | edit source]
Due to its selectivity for the CB2 receptor, JWH-133 is used in scientific research to explore the therapeutic potential of CB2 receptor activation. Studies have investigated its effects in models of neurodegenerative disease, pain management, and cancer.
Legal Status[edit | edit source]
The legal status of JWH-133 varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and its structural similarity to other synthetic cannabinoids that have been used recreationally.
Safety and Toxicity[edit | edit source]
As with many synthetic cannabinoids, the safety profile of JWH-133 is not fully understood. While it is primarily used in research settings, caution is advised due to the potential for unknown side effects and toxicities.
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Contributors: Prab R. Tumpati, MD
