2-Arachidonyl glyceryl ether

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2-Arachidonyl glyceryl ether (2-AGE) is a cannabinoid that is found naturally in the human body. It is also known as noladin ether. It was first described in 2001 and is believed to bind to the CB1 receptor and also the CB2 receptor. It is a full agonist at CB1 and a partial agonist at CB2.

Chemistry[edit | edit source]

2-Arachidonyl glyceryl ether is a type of ether and glycerol ester. It is chemically similar to the endocannabinoids 2-arachidonoylglycerol and anandamide, but has a higher affinity for the CB1 receptor and is more stable in vivo.

Pharmacology[edit | edit source]

2-Arachidonyl glyceryl ether is thought to play a role in the regulation of appetite, pain, inflammation, and memory. It is also thought to be involved in the immune system and may have potential therapeutic applications in conditions such as multiple sclerosis, Parkinson's disease, and cancer.

Research[edit | edit source]

Research into 2-Arachidonyl glyceryl ether is ongoing, with studies investigating its potential therapeutic applications and its role in the endocannabinoid system. It is also being studied for its potential use in the treatment of neurodegenerative diseases and chronic pain.

See also[edit | edit source]


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Contributors: Prab R. Tumpati, MD