Palmitoylethanolamide

From WikiMD's Wellness Encyclopedia

Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide, belonging to the class of nuclear factor agonists. PEA has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation. The main target is thought to be the peroxisome proliferator-activated receptor alpha (PPAR-α).

History[edit | edit source]

PEA was identified in the 1950s as a therapeutic principle in egg yolk. In the 1990s, its anti-inflammatory properties were identified. PEA is currently under investigation in clinical trials for its potential therapeutic role in various diseases.

Pharmacology[edit | edit source]

PEA is an endogenous fatty acid amide and belongs to the class of nuclear factor agonists. PEA has been shown to have anti-inflammatory, analgesic, neuroprotective, and anticonvulsant properties.

Clinical significance[edit | edit source]

PEA has been suggested as a potential therapeutic agent in a variety of disorders, including neuropathic pain, neurodegenerative diseases, and inflammation.

See also[edit | edit source]

References[edit | edit source]


External links[edit | edit source]

Palmitoylethanolamide Resources
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