Neuropathic pain

From WikiMD's Wellness Encyclopedia

Neuropathic pain is a complex, chronic pain state that usually is accompanied by tissue injury. With neuropathic pain, the nerve fibers themselves may be damaged, dysfunctional, or injured, and thus send incorrect signals to other pain centers within the nervous system.

Introduction[edit | edit source]

Neuropathic pain is a type of pain that arises from the malfunction of the nervous system following a nerve injury. This can result from various conditions that involve damage to the peripheral or central nervous system.[1]

Causes[edit | edit source]

Neuropathic pain can be caused by a number of health conditions, such as diabetes, shingles, cancer, multiple sclerosis, HIV infection, chemotherapy, or physical trauma to the nerves. Sometimes, it can also be idiopathic, meaning it has no identifiable cause.[2]

Symptoms[edit | edit source]

Neuropathic pain is often described as a burning or shooting pain. It can be associated with an array of symptoms including spontaneous pain, evoked pain (like hyperalgesia or allodynia), and various abnormal sensations such as tingling, numbness, or an electric shock-like sensation.

Diagnosis[edit | edit source]

Diagnosis of neuropathic pain involves a detailed patient history, physical examination, and sometimes diagnostic tests to identify the underlying cause. This can include nerve conduction studies, electromyography (EMG), or imaging techniques such as MRI.[3]

Treatment[edit | edit source]

Treatment of neuropathic pain can be challenging and often requires a multidisciplinary approach. This can include medications (like antiepileptics, antidepressants, opioids, and topical agents), interventional procedures, physical therapy, psychological support, and sometimes surgery.[4]

See Also[edit | edit source]

References[edit | edit source]

  1. Jensen, T. S., Baron, R., Haanpää, M., Kalso, E., Loeser, J. D., Rice, A. S., & Treede, R. D. (2011). A new definition of neuropathic pain. Pain, 152(10), 2204-2205.
  2. Finnerup, N. B., Haroutounian, S., Kamerman, P., Baron, R., Bennett, D. L., Bouhassira, D., ... & Freeman, R. (2016). Neuropathic pain: an updated grading system for research and clinical practice. Pain, 157(8), 1599-1606.
  3. Backonja, M. M., & Stacey, B. (2004). Neuropathic pain symptoms relative to overall pain rating. The Journal of Pain, 5(9), 491-497.
  4. Finnerup, N. B., Attal, N., Haroutounian, S., McNicol, E., Baron, R., Dworkin, R. H., ... & Wallace, M. (2015). Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. The Lancet Neurology, 14(2), 162-173.
Neuropathic pain Resources
Wikipedia
WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD