JWH-138

JWH-138 is a synthetic cannabinoid from the JWH series. It was discovered by and named after Dr. John W. Huffman. JWH-138 has analgesic effects and is used in scientific research. It is not currently approved for medical use.

Chemistry

JWH-138 is a member of the JWH series of synthetic cannabinoids. It is a complex organic compound with the molecular formula C23H25NO. The compound is made up of a naphthoyl group, a cyclohexylmethyl group, and a hydroxyl group. The naphthoyl group is attached to the cyclohexylmethyl group by a ketone bridge, and the hydroxyl group is attached to the naphthoyl group.

Pharmacology

JWH-138 acts as a potent agonist at the CB1 receptor and CB2 receptor, the two main cannabinoid receptors in the body. It has a binding affinity of 9.0 nM at CB1 and 2.94 nM at CB2. The compound's effects are primarily mediated by its action on these receptors.

Effects

The effects of JWH-138 are similar to those of other cannabinoids. It produces analgesic effects, and may also have anti-inflammatory and neuroprotective effects. However, the compound is not currently approved for medical use, and its safety profile is not well established.

Legal status

JWH-138 is a controlled substance in many countries, including the United States, where it is classified as a Schedule I drug under the Controlled Substances Act.

See also

• JWH-073
• JWH-200
• Cannabinoid receptor
• Synthetic cannabinoids

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  JWH-138 structure
• 
  D3-THC-C8 structure
• 
  d9-THC-C8 structure