L-759,656

L-759,656 is a drug that acts as a potent and selective antagonist for the CB2 receptor, and was developed by Merck & Co. It has analgesic effects and is used in scientific research, but has not been developed for medical use.

Chemistry

L-759,656 is a member of the benzopyran class of compounds and is closely related in structure to the cannabinoid compound nabilone, which is used for the treatment of nausea and vomiting associated with cancer chemotherapy.

Pharmacology

L-759,656 acts as a selective antagonist for the CB2 receptor, with a Ki of 2.4 nM, and has no significant affinity for the CB1 receptor. This selectivity makes it useful in scientific research into the function of the CB2 receptor, as it allows the effects of CB2 activation to be studied in isolation.

Uses

While L-759,656 has not been developed for medical use, it is commonly used in scientific research. Its high selectivity for the CB2 receptor makes it a useful tool in the study of the endocannabinoid system, and it has been used in a number of studies investigating the role of the CB2 receptor in pain and inflammation, immune function, and neurodegenerative diseases.

See also

• Cannabinoid receptor antagonist
• List of investigational analgesics

L-759,656 Resources
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