AM-1241

AM-1241 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 3.4 nM at CB2 and 80 times selectivity over the related CB1 receptor. It has analgesic effects in animal studies, particularly against "atypical" pain types such as hyperalgesia and allodynia.

Pharmacology

AM-1241 is a selective agonist for the cannabinoid receptor CB2. It has a Ki of 3.4 nM at CB2, indicating a high affinity for this receptor. AM-1241 is 80 times more selective for CB2 than the related CB1 receptor. This selectivity is believed to result in fewer psychoactive side effects than non-selective cannabinoid agonists.

Therapeutic Potential

AM-1241 has demonstrated analgesic effects in animal studies. It is particularly effective against "atypical" pain types such as hyperalgesia and allodynia. Hyperalgesia is an increased sensitivity to pain, while allodynia is a condition in which non-painful stimuli can cause pain. AM-1241's effectiveness against these types of pain suggests it may have potential as a therapeutic agent for conditions characterized by these symptoms.

Side Effects

As a selective CB2 agonist, AM-1241 is expected to have fewer side effects than non-selective cannabinoid agonists. However, the specific side effects of AM-1241 have not been extensively studied.

See Also

• Cannabinoid receptor
• Hyperalgesia
• Allodynia

AM-1241 Resources
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