O-2545

O-2545

O-2545 is a synthetic cannabinoid that is used in scientific research. It is a potent and selective agonist for the CB1 receptor, with a Ki value of 11.3 nM, making it around 60 times more potent than THC, the main active principle in cannabis.

Chemistry

O-2545 is a member of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other naphthoylindoles such as JWH-018 and AM-2201, but differs in that it has a fluorine atom on the phenyl ring. This modification is thought to increase the potency of the compound.

Pharmacology

O-2545 acts as a full agonist at the CB1 receptor, which is primarily found in the brain and is responsible for the psychoactive effects of THC. It has a Ki value of 11.3 nM at this receptor, making it significantly more potent than THC, which has a Ki value of around 700 nM. O-2545 also has some affinity for the CB2 receptor, but this is much lower than its affinity for the CB1 receptor.

Effects

The effects of O-2545 in humans are not well studied, as it is primarily used in scientific research. However, based on its pharmacology, it is likely to produce effects similar to those of other potent CB1 agonists, such as intense euphoria, altered perception, and potential for psychosis in susceptible individuals.

Legal Status

The legal status of O-2545 varies by country. In many jurisdictions, it is considered a controlled substance due to its structural similarity to other banned synthetic cannabinoids.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• JWH-018
• AM-2201

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