O-1057

O-1057 is a synthetic cannabinoid that is used in scientific research. It is a potent and selective agonist for the CB1 receptor, with a Ki of 0.16 nM, making it around 25x more potent than THC, the main active principle in cannabis.

Chemistry

O-1057 is a member of the 3-phenylacetylindoles class of synthetic cannabinoids. It has a molecular formula of C24H23NO2 and a molecular weight of 357.44 g/mol. The systematic name for O-1057 is (6aR,10aR)-3-(1,1-Dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran.

Pharmacology

O-1057 acts as a potent and selective agonist for the CB1 receptor, which is primarily located in the brain. This receptor is one of the two main types of cannabinoid receptors in the body, the other being the CB2 receptor which is mainly found in the immune system. Activation of the CB1 receptor produces psychoactive effects, which is why substances like THC and O-1057 have recreational use potential.

Research Use

Due to its potency and selectivity for the CB1 receptor, O-1057 is used in scientific research to study the function of this receptor. It can be used in experiments to activate the CB1 receptor in a controlled way, allowing researchers to investigate the effects of this activation on various biological processes.

Legal Status

The legal status of O-1057 varies by country. In some jurisdictions, it is classified as a controlled substance due to its psychoactive properties. However, in other places it may be legal to possess and use for research purposes.

See Also

• Cannabinoid
• CB1 receptor
• THC
• 3-phenylacetylindoles