JWH-139

JWH-139 is a synthetic cannabinoid that acts as a potent agonist at both the CB1 and CB2 receptors. It is part of the naphthoylindole family of compounds, which are known for their high affinity and selectivity for cannabinoid receptors. JWH-139 was developed by Dr. John W. Huffman and his team at Clemson University as part of their research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-139 is chemically classified as a naphthoylindole, which is characterized by a naphthalene group attached to an indole core. The chemical formula for JWH-139 is C24H26O, and it has a molecular weight of 330.47 g/mol. The compound is typically synthesized through a series of organic reactions involving the condensation of naphthalene derivatives with indole moieties.

Pharmacology

JWH-139 exhibits high affinity for the CB1 and CB2 receptors, with a slight preference for the CB2 receptor. This selectivity makes it a valuable tool for studying the role of cannabinoid receptors in various physiological processes. The activation of CB1 receptors by JWH-139 is associated with psychoactive effects, while CB2 receptor activation is linked to anti-inflammatory and immunomodulatory effects.

Legal Status

The legal status of JWH-139 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. Researchers must obtain special licenses to study JWH-139 and similar synthetic cannabinoids.

Research Applications

JWH-139 is primarily used in scientific research to explore the effects of cannabinoid receptor activation. Studies have investigated its potential therapeutic applications, including pain management, neuroprotection, and anti-inflammatory effects. However, due to its psychoactive properties, its use in clinical settings is limited.

Safety and Toxicology

The safety profile of JWH-139 is not well-established, as it is primarily used in laboratory settings. Like other synthetic cannabinoids, it may pose risks of adverse effects, including anxiety, tachycardia, and hallucinations. Long-term effects are not well understood, and caution is advised when handling this compound.

Also see

• Synthetic cannabinoids
• CB1 receptor
• CB2 receptor
• John W. Huffman
• Cannabinoid receptor agonists