Pipoxizine

Pipoxizine is a tricyclic antidepressant (TCA) that was developed in the 1960s. It is a member of the dibenzazepine group of TCAs and is structurally related to imipramine and desipramine. Pipoxizine was never marketed.

Pharmacology

Pipoxizine acts as a norepinephrine reuptake inhibitor and antihistamine. It is known to have antidepressant, anxiolytic, and antiemetic effects.

History

Pipoxizine was developed in the 1960s but was never marketed. The reasons for this are not clear, but it may be due to the drug's side effects or lack of efficacy compared to other TCAs.

Side Effects

Like other TCAs, pipoxizine can cause a variety of side effects. These may include dry mouth, constipation, blurred vision, urinary retention, and orthostatic hypotension. In rare cases, it can cause more serious side effects such as cardiac arrhythmias or seizures.

See Also

• List of antidepressants
• List of withdrawn drugs

References

Pipoxizine Resources
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