Substituted alpha-alkyltryptamine

Substituted alpha-alkyltryptamine is a class of psychedelic drugs that includes a variety of compounds with a common structural feature, an indole ring substituted at the alpha position with an alkyl group. These compounds are derived from the essential amino acid tryptophan and are known for their hallucinogenic properties.

History

The history of substituted alpha-alkyltryptamines dates back to the mid-20th century when the first compound of this class, DMT (Dimethyltryptamine), was synthesized. Since then, numerous other compounds have been discovered and synthesized, including 5-MeO-DMT and AMT (Alpha-Methyltryptamine).

Chemistry

Substituted alpha-alkyltryptamines are characterized by a common structural feature, an indole ring substituted at the alpha position with an alkyl group. The indole ring is a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. The alkyl group at the alpha position can vary, leading to a wide range of compounds within this class.

Pharmacology

The pharmacological effects of substituted alpha-alkyltryptamines are primarily due to their action as serotonin receptor agonists. They bind to and activate the serotonin receptors in the brain, leading to a range of effects including hallucinations, altered perception of time and space, and enhanced sensory experiences.

Legal Status

The legal status of substituted alpha-alkyltryptamines varies by country. In many countries, including the United States, these compounds are classified as Schedule I drugs, indicating that they have a high potential for abuse and no accepted medical use.

See Also

• Tryptamine
• Psychedelic drug
• Serotonin receptor