Substituted tryptamine

Substituted tryptamine refers to a class of molecules that are structurally derived from the tryptamine molecule. The tryptamine structure is the backbone for a group of compounds termed collectively as substituted tryptamines. This class of drug contains a broad range of psychedelic, stimulant, and antidepressant effects.

Structure and Function

Substituted tryptamines have the same core structure as tryptamine, but with additional substituents attached to the molecule. The structure of tryptamine is a combination of an indole ring and an ethylamine side chain. The substitutions can occur at various positions on the tryptamine molecule, leading to a wide variety of compounds with different effects.

Pharmacology

The pharmacology of substituted tryptamines is complex and varies depending on the specific compound. Many substituted tryptamines are serotonin agonists, meaning they bind to and activate serotonin receptors in the brain. This can lead to a range of effects, including hallucinations, altered perception, and mood elevation.

Examples of Substituted Tryptamines

There are many examples of substituted tryptamines, including both naturally occurring compounds and synthetic drugs. Some examples include:

• Psilocybin: A naturally occurring psychedelic compound found in certain species of mushrooms.
• DMT (Dimethyltryptamine): A powerful psychedelic compound found in a variety of plant species, and in trace amounts in the human body.
• AMT (Alpha-Methyltryptamine): A synthetic compound with stimulant, psychedelic, and entactogenic effects.

Legal Status

The legal status of substituted tryptamines varies greatly by country and by specific compound. In many countries, including the United States, many substituted tryptamines are classified as controlled substances, making their manufacture, sale, and possession illegal.

See Also

• Phenethylamine
• Lysergamide
• Psychedelic drug