Methoctramine
Methoctramine is a muscarinic antagonist with selectivity for the M2 subtype. It is used in scientific research to understand the interaction between the nervous system and various organs in the body.
Pharmacology[edit | edit source]
Methoctramine acts as an antagonist at the M2 muscarinic acetylcholine receptor. This receptor subtype is found in the heart and is involved in slowing the heart rate. By blocking this receptor, methoctramine can increase heart rate. This makes it a useful tool in research to understand the role of the parasympathetic nervous system in heart function.
Chemistry[edit | edit source]
Methoctramine is a quaternary ammonium compound. It has two tropane rings, which are bridged by a nonane chain. This structure is thought to be responsible for its selectivity for the M2 receptor.
Uses in Research[edit | edit source]
Methoctramine is used in research to study the role of the M2 receptor in various physiological processes. For example, it has been used to investigate the role of this receptor in heart rate regulation, gastrointestinal motility, and the release of various neurotransmitters.
Side Effects[edit | edit source]
As with all drugs, methoctramine can have side effects. These can include dry mouth, blurred vision, and urinary retention. However, these side effects are generally mild and transient.
See Also[edit | edit source]
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