Himbacine
Himbacine is an alkaloid isolated from the bark of Australian magnolias. Himbacine has been synthesized using a Diels-Alder reaction as a key step.[1] Himbacine's activity as a muscarinic receptor antagonist, with specificity for the Muscarinic acetylcholine receptor M2, made it a promising starting point in Alzheimer's disease research.[2][3] The development of a muscarinic antagonist based on Himbacine failed but an analog is now in clinical trials as a thrombin receptor antagonist.[4][5]
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Contributors: Prab R. Tumpati, MD
