Loxapine

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What is Loxapine?[edit | edit source]

Loxapine
Loxapine2D
Loxapine
Loxapine3D


What are the uses of this medicine?[edit | edit source]

  • Adasuve is a prescription medicine that is inhaled through your mouth and is used to treat acute agitation in adults with schizophrenia or bipolar I disorder.


How does this medicine work?[edit | edit source]

  • The mechanism of action of loxapine in the treatment of agitation associated with schizophrenia is unknown.
  • However, its efficacy could be mediated through a combination of antagonism of central dopamine D 2 and serotonin 5-HT 2A receptors.
  • The mechanism of action of loxapine in the treatment of agitation associated with bipolar I disorder is unknown.


Who Should Not Use this medicine ?[edit | edit source]

This medicine cannot be used in patients who:

  • have or have had asthma, chronic obstructive pulmonary disease (COPD), or other airway or lung problems that can cause bronchospasm
  • are having problems with wheezing, coughing, chest tightness, or shortness of breath
  • are taking medicines to treat asthma or COPD
  • have taken Adasuve before and had bronchospasm
  • are allergic to loxapine or amoxapine


What drug interactions can this medicine cause?[edit | edit source]


Is this medicine FDA approved?[edit | edit source]

  • The US Food and Drug Administration (FDA) has approved in the year of 1975 for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults.


How should this medicine be used?[edit | edit source]

  • Administer only a single dose within any 24-hour period
  • Prior to administering, screen all patients for a history of pulmonary disease, and examine patients (including chest auscultation) for respiratory abnormalities (e.g. wheezing) .

Recommended dosage:

  • 10 mg by oral inhalation using an inhaler.
  • Administer only a single dose within any 24-hour period.

Administration:

  • Your healthcare provider will show you how to take Adasuve right before you take it.
  • Take Adasuve exactly as your healthcare provider shows you to take it.
  • Adasuve is for oral inhalation only.


What are the dosage forms and brand names of this medicine?[edit | edit source]

This medicine is available in fallowing doasage form:

  • As Inhalation powder: 10 mg unit in a single-use inhaler
  • Loxapine Capsules

This medicine is available in fallowing brand namesː

  • Adasuve(inhalation only) LOXAPINE capsule


What side effects can this medication cause?[edit | edit source]

The most common side effects of this medicine include:

  • bad, bitter, or metallic taste in your mouth (dysgeusia)
  • sleepiness (especially when used with other drugs that cause sleepiness)
  • sore throat

This medicine may cause serious side effects, including:

  • Narrowing of the airways (bronchospasm) that can cause you to have problems breathing or to stop breathing
  • Increased risk of death in elderly patients with dementia-related psychosis


What special precautions should I follow?[edit | edit source]

  • Do not drive, operate heavy machinery, or do other dangerous activities until you know how Adasuve affects you.
  • Do not drink alcohol while taking Adasuve. It can increase your chances of getting serious side effects.
  • Neuroleptic Malignant Syndrome may develop in patients treated with antipsychotic drugs. Discontinue treatment.
  • Adasuve can cause hypotension, orthostatic hypotension, and syncope. Use with caution in patients with known cardiovascular or cerebrovascular disease.
  • Seizures have occurred in patients treated with oral loxapine. Adasuve lowers the seizure threshold. Use with caution in patients with a history of seizures or with conditions that lower the seizure threshold.
  • Adasuve can impair judgment, thinking, and motor skills. Use caution when driving or operating machinery
  • cerebrovascular adverse reactions (stroke and transient ischemic attacks), including fatalities have occured. Increased incidence of stroke and transient ischemic attack in elderly patients with dementia-related psychosis treated with antipsychotic drugs.


What to do in case of emergency/overdose?[edit | edit source]

Symptoms of overdosage may include:

Management of overdosage:

  • Provide supportive care including close medical supervision and monitoring.
  • Treatment should consist of general measures employed in the management of overdosage with any drug.
  • Consider the possibility of multiple drug overdosage.
  • Ensure an adequate airway, oxygenation, and ventilation.
  • Monitor cardiac rhythm and vital signs. Use supportive and symptomatic measures.
  • Contact a certified poison control center (1-800-222-1222 or www.poison.org).


Can this medicine be used in pregnancy?[edit | edit source]

  • There are no adequate and well-controlled studies of Adasuve use in pregnant women.
  • Adasuve should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.


Can this medicine be used in children?[edit | edit source]

  • The safety and effectiveness of Adasuve in pediatric patients have not been established.


What are the active and inactive ingredients in this medicine?[edit | edit source]

  • Active Ingredient: loxapine
  • Inactive Ingredients: none


Who manufactures and distributes this medicine?[edit | edit source]


What should I know about storage and disposal of this medication?[edit | edit source]

  • Store Adasuve at room temperature, 15° to 30°C (59° to 86°F) .
  • Keep out of reach of children.
  • Keep Adasuve in pouch until time of use.
  • Adasuve contains a lithium battery. Dispose of Adasuve in accordance with all federal, state and local laws.
  • Adasuve is only available through a restricted program called the Adasuve REMS Program.

Antipsychotic agents[edit source]

First Generation

Second Generation (Atypicals)

Loxapine Resources

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The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone

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