Lumateperone
Lumateperone (also known as ITI-007) is an antipsychotic medication developed by Intra-Cellular Therapies for the treatment of schizophrenia, bipolar disorder, and depression. It was approved by the FDA in December 2019 for the treatment of schizophrenia in adults.
Mechanism of Action[edit | edit source]
Lumateperone acts as a serotonin receptor antagonist, dopamine receptor phosphoprotein modulator, and glutamate receptor modulator. It has a unique mechanism of action that differs from other antipsychotic drugs.
Medical Uses[edit | edit source]
Lumateperone is used primarily for the treatment of schizophrenia in adults. It is also being investigated for potential use in treating bipolar disorder and depression.
Side Effects[edit | edit source]
Common side effects of lumateperone include somnolence, nausea, dry mouth, and weight gain. Serious side effects may include neuroleptic malignant syndrome, tardive dyskinesia, and orthostatic hypotension.
History[edit | edit source]
Lumateperone was developed by Intra-Cellular Therapies and received FDA approval in December 2019. It is marketed under the brand name Caplyta.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
