Tolonidine

Tolonidine is a pharmacological agent that belongs to the class of antihypertensive drugs. It is primarily used in the treatment of hypertension, a condition characterized by persistently elevated blood pressure.

Pharmacology[edit | edit source]

Tolonidine is a centrally acting alpha-2 adrenergic agonist. It works by stimulating alpha-2 adrenergic receptors in the brain, which results in a decrease in sympathetic nervous system activity. This, in turn, leads to a reduction in heart rate and blood pressure.

Clinical Use[edit | edit source]

Tolonidine is used in the management of hypertension. It is often used in combination with other antihypertensive drugs to achieve optimal blood pressure control. The drug is typically administered orally, and the dosage is adjusted based on the patient's response to treatment.

Side Effects[edit | edit source]

Like all medications, Tolonidine can cause side effects. Common side effects include drowsiness, dry mouth, and fatigue. Less common but more serious side effects can include bradycardia, hypotension, and depression.

Contraindications[edit | edit source]

Tolonidine is contraindicated in patients with known hypersensitivity to the drug. It should also be used with caution in patients with severe heart disease, kidney disease, or liver disease.

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