Carazolol

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A beta-adrenergic antagonist used in veterinary medicine


Carazolol
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Carazolol is a non-selective beta-adrenergic antagonist primarily used in veterinary medicine. It is known for its high affinity for beta-adrenergic receptors and is utilized in various animal species to manage stress and improve meat quality.

Pharmacology[edit | edit source]

Carazolol acts by blocking the action of catecholamines such as epinephrine and norepinephrine on beta-adrenergic receptors. This action results in decreased heart rate and reduced cardiac output, which can be beneficial in managing stress responses in animals.

Mechanism of Action[edit | edit source]

Carazolol binds to beta-adrenergic receptors, preventing the binding of endogenous catecholamines. This blockade leads to a decrease in the activation of adenylate cyclase, reducing the conversion of ATP to cAMP, and ultimately decreasing the physiological effects mediated by beta-adrenergic stimulation.

Uses in Veterinary Medicine[edit | edit source]

Carazolol is used in various animal species, including pigs, cattle, and poultry, to manage stress during transport and slaughter. It helps in reducing the incidence of stress-related conditions such as porcine stress syndrome and improves meat quality by minimizing glycogen depletion and lactic acid accumulation in muscles.

Side Effects[edit | edit source]

While carazolol is generally well-tolerated in animals, potential side effects include bradycardia, hypotension, and respiratory distress. Careful dosing and monitoring are essential to minimize adverse effects.

Regulatory Status[edit | edit source]

Carazolol is approved for use in veterinary medicine in several countries. However, its use is subject to strict regulations to ensure animal welfare and food safety.

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