Ecastolol
A comprehensive overview of the beta-blocker Ecastolol
Ecastolol[edit | edit source]
Ecastolol is a beta-blocker medication primarily used in the management of hypertension and certain types of cardiac arrhythmias. It functions by blocking the effects of epinephrine (adrenaline) on the beta-adrenergic receptors in the heart, which results in a decrease in heart rate and blood pressure.
Pharmacology[edit | edit source]
Ecastolol is a selective beta-1 adrenergic receptor antagonist. This selectivity means it primarily affects the heart and has less impact on beta-2 receptors found in the lungs and vascular smooth muscle. This property makes it a preferred choice in patients with asthma or chronic obstructive pulmonary disease (COPD), as it is less likely to cause bronchoconstriction.
Mechanism of Action[edit | edit source]
Ecastolol works by inhibiting the action of catecholamines, such as epinephrine and norepinephrine, on beta-1 adrenergic receptors. This leads to a reduction in myocardial contractility and heart rate, thereby decreasing cardiac output and lowering blood pressure. Additionally, it reduces the release of renin from the kidneys, contributing to its antihypertensive effects.
Clinical Uses[edit | edit source]
Ecastolol is indicated for the treatment of:
- Hypertension
- Angina pectoris
- Heart failure
- Myocardial infarction
- Certain types of arrhythmias, such as atrial fibrillation
Side Effects[edit | edit source]
Common side effects of Ecastolol include:
Serious side effects may include:
- Heart block
- Heart failure
- Bronchospasm in susceptible individuals
Contraindications[edit | edit source]
Ecastolol should not be used in patients with:
Administration[edit | edit source]
Ecastolol is typically administered orally, with dosage adjusted based on the patient's response and clinical condition. It is important to monitor blood pressure and heart rate regularly during treatment.
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