Chanoclavine

Chanoclavine is a type of ergoline alkaloid. It is a precursor in the biosynthesis of other ergoline alkaloids. Chanoclavine is produced by various species of fungi, including Aspergillus and Penicillium.

Biosynthesis

Chanoclavine is synthesized from tryptophan and dimethylallyl pyrophosphate (DMAPP). The first step in the biosynthesis of chanoclavine is the prenylation of tryptophan by the enzyme DMAT synthase, which transfers the dimethylallyl group from DMAPP to tryptophan, forming dimethylallyltryptophan (DMAT). DMAT is then converted to chanoclavine by a series of enzymatic reactions.

Biological activity

Chanoclavine has been found to have antibacterial activity. It also has been shown to inhibit the growth of certain types of cancer cells.

See also

• Ergoline
• Ergot alkaloid

References

Chanoclavine Resources
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