Diacetolol

Diacetolol is a pharmacological agent that belongs to the class of beta blockers. It is a metabolite of acebutolol, a cardioselective beta blocker used in the treatment of hypertension and arrhythmia.

Pharmacodynamics[edit | edit source]

Diacetolol acts as a beta-adrenergic antagonist, blocking the action of epinephrine and norepinephrine on beta receptors. This results in a decrease in heart rate, cardiac output, and blood pressure. It is a non-selective beta blocker, meaning it blocks both beta-1 and beta-2 receptors.

Pharmacokinetics[edit | edit source]

Diacetolol is primarily excreted in the urine, with a half-life of approximately 10-12 hours. It is metabolized in the liver by the cytochrome P450 enzyme system.

Clinical Use[edit | edit source]

Diacetolol is used in the treatment of hypertension and arrhythmia. It may also be used in the management of angina pectoris, myocardial infarction, and heart failure.

Side Effects[edit | edit source]

Common side effects of Diacetolol include fatigue, dizziness, and bradycardia. Less common side effects may include gastrointestinal disturbances, sleep disturbances, and depression.

Contraindications[edit | edit source]

Diacetolol is contraindicated in patients with asthma, bradycardia, and heart block. It should be used with caution in patients with diabetes and peripheral vascular disease.

Interactions[edit | edit source]

Diacetolol may interact with other medications, including other beta blockers, calcium channel blockers, and digoxin.

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