Diacetolol

Diacetolol

Diacetolol is a pharmacological agent that belongs to the class of beta blockers. It is a metabolite of acebutolol, a cardioselective beta blocker used in the treatment of hypertension and arrhythmia.

Pharmacodynamics

Diacetolol acts as a beta-adrenergic antagonist, blocking the action of epinephrine and norepinephrine on beta receptors. This results in a decrease in heart rate, cardiac output, and blood pressure. It is a non-selective beta blocker, meaning it blocks both beta-1 and beta-2 receptors.

Pharmacokinetics

Diacetolol is primarily excreted in the urine, with a half-life of approximately 10-12 hours. It is metabolized in the liver by the cytochrome P450 enzyme system.

Clinical Use

Diacetolol is used in the treatment of hypertension and arrhythmia. It may also be used in the management of angina pectoris, myocardial infarction, and heart failure.

Side Effects

Common side effects of Diacetolol include fatigue, dizziness, and bradycardia. Less common side effects may include gastrointestinal disturbances, sleep disturbances, and depression.

Contraindications

Diacetolol is contraindicated in patients with asthma, bradycardia, and heart block. It should be used with caution in patients with diabetes and peripheral vascular disease.

Interactions

Diacetolol may interact with other medications, including other beta blockers, calcium channel blockers, and digoxin.

See Also

• Beta blocker
• Acebutolol
• Hypertension
• Arrhythmia