Rauwolscine

Rauwolscine is a naturally occurring alkaloid found in various species of plants. It is structurally related to yohimbine and acts as an antagonist at alpha-2 adrenergic receptors, leading to increased levels of norepinephrine/noradrenaline. It is used in research to distinguish between different types of adrenergic receptors.

Chemistry[edit | edit source]

Rauwolscine is an indole alkaloid that is derived from the bark of the Rauwolfia serpentina plant, also known as the Indian Snakeroot or Sarpagandha. It is chemically similar to yohimbine and reserpine, other alkaloids derived from the same plant.

Pharmacology[edit | edit source]

Rauwolscine acts as an antagonist at alpha-2 adrenergic receptors. These receptors are found in the brain and peripheral nervous system and are involved in a variety of physiological processes, including the regulation of blood pressure, heart rate, and stress responses. By blocking these receptors, rauwolscine increases the release of norepinephrine/noradrenaline, a neurotransmitter that plays a key role in the body's fight-or-flight response.

Uses[edit | edit source]

Rauwolscine is primarily used in research to help distinguish between different types of adrenergic receptors. It is also sometimes used as a dietary supplement for its purported fat-burning properties, although there is limited scientific evidence to support this use.

Safety[edit | edit source]

The safety of rauwolscine is not well-studied. It is known to cause side effects such as insomnia, anxiety, and increased heart rate in some individuals. It is not recommended for use by individuals with heart disease, high blood pressure, or other cardiovascular conditions.

See Also[edit | edit source]

Rauwolscine Resources
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